In a study by Dong et al. [105], inhibition of the tumor suppressor microRNA-137 (miR-137) through methylation of its promoter by DNA methyltransferases (DNMTs) together with methyl-CpG-binding protein 2 (MeCP2) led to ASCT2 upregulation and, consequently, glutamine metabolism reactivation, identifying miR-137 as a regulator of glutaminolysis by targeting ASCT2 [105]. Here, SLC1A5 is linked to neoplasm.