A reciprocal regulatory connection has also been observed between ASCT2, LAT1 and mTOR in prostate cancer, hepatoma, lymphoma and leukemic cells, since glutamine starvation-induced LAT1-mediated transport of amino acids or expression and/or leucine deprivation induced the same effects on ASCT2 [3,38,67]. Here, SLC7A5 is linked to hepatocellular carcinoma.