Moreover, cholangiocarcinoma cells ability to migrate and invade was reduced by a downregulation of LAT1 expression through shRNA and it is suggested that it may involve 4F2hc-related signaling, since this molecule interacts with β1 integrin and forms a complex that takes part in Akt signaling activation, contributing to carcinogenesis [73]. This evidence concerns the gene SLC7A5 and cholangiocarcinoma.