BACE1 and Alzheimer disease: Recent pathways to control AD include termination of the physiological role of cholinergic synapses and β-amyloid formation via inhibition of the key enzymes, acetylcholinesterase (AChE), butуrylсholinesterase (BChE), and β-secretase (β-site amyloid precursor protein cleaving enzyme 1 or BACE-1) [12,13,14,15].