Furthermore, we proposed a post-transcriptional mechanism, by which activation of the EEF1A2/PI3K/AKT/mTOR signaling axis fosters the protumorigenic function of MDM4 in human HCC and showed that the MDM4 protein level is associated with the survival probability of HCC patients following liver resection [20]. Here, AKT1 is linked to hepatocellular carcinoma.