Common genetic polymorphisms in patatin-like phospholipase domain-containing 3 (PNPLA3) at rs738409, transmembrane 6 superfamily member 2 (TM6SF2) at rs58542926, membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) at rs641738 and 17-beta-hydroxysteroid dehydrogenase (HSD17B13) at rs72613567 have been shown to robustly influence the risk of NAFLD-fibrosis [14]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.