TYMS and malignant colon neoplasm: Further, 5-FU-resistant cells overexpress DPYD acquiring resistance to 5-FU, which was reversed with transfection with miR-494 mimics, and miR-330 increased 5-FU-chemosensitivity in colon cancer cell lines through direct downregulation of TYMS expression, both increasing apoptosis induced by this chemotherapeutic agent in colon cancer cells [55,58].