Le Guellec et al performed genomic sequencing using 260 desmoid tumors and 191 desmoid-like spindle cell lesions.[11] They demonstrated that 88% of the desmoid tumors showed exclusively CTNNB1 mutations, suggesting that detection of these mutations could be useful for discriminating desmoid tumors from other spindle cell tumors.[11] A subsequent study using various molecular profiling methods, including whole-exome sequencing, demonstrated that the genetic alterations in CTNNB1 were almost universal in sporadic desmoid tumors.[31]. This evidence concerns the gene CTNNB1 and spindle cell neoplasm.