TFRC and major depressive disorder: The mutation of TFRC was found to be associated with immunodefificiency 46 (OMIM: 616740).[7] It could be abnormally overexpressed in epithelial ovarian cancer.[19] Downregulation of TFRC is predictive of recurrent Major Depressive Disorder (MDD), which may indicate the role of the innate immune system in depression.[20]XXYLT1 (OMIM: 614552), known as Xyloside α-1,3-xylosyltransferase, is a retaining Glycosyltransferase of the GT8 family.