The NPM1 mutation was also positively correlated with high white blood cell counts in our AML patients, and it frequently found in conjunction with the FLT3-ITD mutation.[17,18] The NPM1 mutation is present in ∼30% of AML cases, but it is less common in hypocellular AML than in non-hypocellular AML. The gene discussed is NPM1; the disease is acute myeloid leukemia.