Our initial motivation to study PTEN was that it regulates brain development and synaptic/neuronal functions (Backman et al, 2001; Endersby & Baker, 2008) and is also implicated in brain disorders, including macrocephaly, epilepsy, Rett syndrome, and autism spectrum disorders (ASD) (Crespi et al, 2010; Tilot et al, 2016). Here, PTEN is linked to brain disorder.