TP53 and Familial prostate cancer: Subsequently, KEGG pathway analysis indicated that these dysregulated DE-mRNAs were remarkably enriched in damage repair, cell death, and cancer-related pathways, including the p53 signaling pathway [27, 28], mismatch repair [29, 30], cellular senescence [31], ferroptosis [32, 33], prostate cancer, and small-cell lung cancer.