Except for two conflicting reports that investigated hypomethylation of the intron 1 CpG island of SNCA in PD and control post‐mortem brain samples, studies of epigenetic factors regulating the α‐synuclein gene in PD have been limited (Guhathakurta et al, 2017a; Guhathakurta et al, 2017b). This evidence concerns the gene SNCA and Parkinson disease.