In B-ALL cell lines, an inverse correlation between the methylation state of the CCN2 locus and CCN2 gene expression was found: B-ALL cell lines with unmethylated CCN2 CpG islands showed high levels of CCN2 expression, while those with methylated CCN2 CpG islands showed no measurable CCN2 expression (Welch et al. 2013). This evidence concerns the gene CCN2 and acute lymphoblastic leukemia.