CCN2 and acute lymphoblastic leukemia: In a study on 79 adult ALL specimens, a higher CCN2 expression level in blood or BM lymphoblasts was an independent negative predictor of survival in a multivariate proportional hazards model and correlated with the percentage of CD34 expressing blasts, although there was no correlation between CCN2 expression levels and rate of complete remission or resistant disease (Sala-Torra et al. 2007).