The TGF-β pathway has already been implicated in the pathogenesis of many BM disorders, including myeloid neoplasms (Bataller et al. 2019), and TGF-β is known to play a central role in the induction of BM fibrosis in myeloproliferative neoplasms (Agarwal et al. 2016). The gene discussed is TGFB1; the disease is myeloproliferative disorder.