In pediatric B-ALL, increased CCN2 expression has been associated with certain cytogenetic subgroups; B-ALL with BCR-ABL, ETV6-RUNX1 (TEL-AML1) or translocations of MLL showed high CCN2 expression (Boag et al. 2007; Gandemer et al. 2007; Tesfai et al. 2012), while those with hyperdiploidy showed low CCN2 expression, and B-ALL with an E2A-PBX1 translocation showed hardly any CCN2 expression (Boag et al. 2007). Here, RUNX1 is linked to precursor B-cell acute lymphoblastic leukemia.