CCN2 and precursor B-cell acute lymphoblastic leukemia: The CCN2 locus contains a dense CpG island at the 5′ end of the coding region and demethylation of this region was shown to be a common feature of pediatric B-ALL; mononuclear cells extracted from BM of these patients showed this locus to be largely unmethylated, regardless of the level of CCN2 gene expression (Welch et al. 2013).