And whereas Johnson et al. showed recombinant CCN1 to inhibit growth of MM cells (Johnson et al. 2014), the viability of primary myeloma cells in the study of Dotterweich et al. increased significantly after CCN1 incubation, implying a pro-myeloma effect of CCN1 (Dotterweich et al. 2014). The gene discussed is CCN1; the disease is Miyoshi myopathy.