CCN2 and acute myeloid leukemia: One study indicates a pro-leukemic effect; transgenic mice overexpressing CCN2 in stromal cells, injected with AML cells, show: (1) a fourfold (time-dependent) enhancement of leukemia engraftment, (2) a higher percentage of leukemia cells in the peripheral blood, and (3) more leukemia engraftment in spleens compared with WT mice (Battula et al. 2017).