CCN2 and precursor B-cell acute lymphoblastic leukemia: B-ALL cells can also secrete CCN2 (Boag et al. 2007; Welch et al. 2015; Wells et al. 2016), and addition of rhCCN2 promotes adhesion of B-ALL cells to stromal cells in vitro, which induces them to overexpress genes associated with cell cycle, intracellular transport and ECM synthesis (Wells et al. 2016).