CCN2 and precursor B-cell acute lymphoblastic leukemia: Lymphoblast from both pediatric and adult B-acute lymphoblastic leukemias (B-ALL) show moderate to highly increased CCN2 mRNA expression compared with control cells (often CD34 positive cells, CD19+igM− cells or mononuclear cells) in the majority (60–80%) of cases (Boag et al. 2007; Sala-Torra et al. 2007; Vorwerk et al. 2000, 2002).