In (T- and B-) ALL and CML, CCN1 expression has been detected in cell lines, and increased CCN1 levels have been demonstrated in BM-derived mononuclear cells, BM aspirate supernatant, and plasma samples of ALL and CML patients (Cao et al. 2019; Song et al. 2019; Zhu et al. 2016). Here, CCN1 is linked to acute lymphoblastic leukemia.