CCN2 and acute lymphoblastic leukemia: Remarkably, CD34 + cells from normal BM also showed extensive hypomethylation of the CCN2 locus, while BM lymphoblasts from T-ALL patients, not expressing detectable levels of CCN2 mRNA, showed hypermethylation focused at either end of the CCN2 CpG island (Welch et al. 2013).