However, in a combined model with plasma p-tau181, the association in CU individuals was no longer significant for NfL, whereas in CImp, longitudinal changes of both plasma markers were independently associated with variations in cognitive decline (CU: p-tau181, β = −0.23; 95% CI, −0.38 to −0.10; NfL, β = −0.04; 95% CI, −0.22 to 0.12; CImp: p-tau181, β = 0.28; 95% CI, 0.17-0.39; NfL, β = 0.23; 95% CI, 0.10-0.38) (eFigure 18A in Supplement 1). The gene discussed is NEFL; the disease is Mental deterioration.