Similar nonspecific results were observed for cognitive changes: plasma NfL changes were associated with a cognitive decline in CImp Aβ− and Aβ+ participants (Aβ− CImp: r = 0.25, P < .001; Aβ+ CImp: r = 0.26, P < .001) but not in CU Aβ− (r = −0.13, P = .06) or CU Aβ+ (r = −0.11, P = .30) participants. The gene discussed is NEFL; the disease is Mental deterioration.