This finding likely corresponds to the accumulation of neurofibrillary tangle pathology, which has been previously found to independently contribute to cognitive impairment beyond hypometabolism and atrophy measures.49,50,51 However, in the current study, we could not confirm this hypothesis owing to the lack of concurrent tau PET scans and plasma p-tau181 measures in the ADNI cohort. Here, MAPT is linked to Cognitive impairment.