NEFL and Alzheimer disease: Plasma NfL changes were also significantly associated with progressive neurodegeneration in AD-typical areas (FDG PET SUVR change: CU, r = −0.20, P = .008; CImp, r = −0.27, P < .001; gray matter volume change: CU, r = −0.11, P = .05; CImp, r = −0.26, P < .001); however, the spatial pattern also involved other frontoparietal regions less characteristic of AD-typical neurodegeneration (Figure 3A and B).