DAPK1 and neoplasm: Whilst the full functional impact of E6-mediated modulation of the host methylome remains to be understood, it has been shown that E6 expression leads to hypermethylation and hence silencing of the death associated protein kinase 1 (DAPK1) promoter, a tumour suppressor that is a key mediator of IFNγ-induced, as well as apoptotic, cell death [174].