In addition to this, a genome-wide reduction in levels of the repressive histone mark H3K27me3 has been reported in HPV16 E7-expressing keratinocytes due to transcriptional induction of the KDM6A and KDM6B lysine demethylases, whilst KDM6A expression is also significantly upregulated in HPV+ tumours [247, 248]. Here, KDM6A is linked to neoplasm.