A direct link between senescence and neurodegeneration has been reported in the MAPTP301SPS19 mouse model of Alzheimer’s disease as increased p16INK4a and β-galactosidase activity in microglia and astrocytes was observed in the cortex and hippocampus during disease progression and removal of p16INK4a positive senescent cells reduced neurodegeneration and cognitive decline (Bussian et al., 2018). The gene discussed is CDKN2A; the disease is early-onset autosomal dominant Alzheimer disease.