GHRL and Myocardial fibrosis: In particular, ghrelin could suppress cardiac fibrosis [67]; GHS-R1a deficiency increased Wnt/beta-catenin pathway activation in isoproterenol-induced myocardial fibrosis and induced inflammasome activation with the release of IL-18 [68], the cardioprotective effect of ghrelin against cardiac remodeling may through activating of JAK2/STAT3 signaling and inhibition of STAT1 signaling [69].