For instance, VCP, hnRNPA1, and hnRNPA2B1 mutations cause multisystem proteinopathy with Paget’s disease of bone, inclusion body myopathy, ALS, and FTD; TIA1 and MATR3 mutations result in distal myopathy in addition to ALS and FTD. This evidence concerns the gene MATR3 and amyotrophic lateral sclerosis.