An identical pattern was observed in a patient with the MATR3(Phe115Cys) mutation (81), and cytoplasmic MATR3 aggregates are also found in patients with FUS mutation–linked ALS (89), suggesting a conserved pattern of MATR3 mislocalization in disease similar to that displayed by TDP-43. Here, MATR3 is linked to amyotrophic lateral sclerosis.