CHGA and diabetes mellitus: The percentages of cells positive for ChgA and negative for 4H rose progressively, being lowest in the non-DM, then rising from early-DM, through intermediate-DM, and finally being highest in the advanced-DM specimens (4% ± 2% vs. 16% ± 5%, 21% ± 7%, 25% ± 7%, respectively) (P< 0.001) (Figure 2B).