As discussed below (and in Appendix 1), they fulfill pro-oncogenic functions by promoting cell proliferation (FOXG1, MAPK13, PNCK, TRIB2), evasion of cell death (MAPK13, PNCK, TP73), replicative immortality (NOVA1), reprogramming of energy metabolism of cancer cells (G6PD, SLC16A3, SLC2A1, SLC2A8), inducing tumor promoting inflammation (CX3CR1, MAPK13) and invasion and metastasis (CX3CR1, TBXA2R). The gene discussed is TRIB2; the disease is neoplasm.