Negatively selected, TEGs identified in the present study do include proteins involved in cell-level processes: they promote cell proliferation (FOXG1, MAPK13, PNCK, and TRIB2), evasion of cell death (MAPK13, PNCK, and TP73), replicative immortality (e.g. NOVA1), or they are crucial for the reprogramming of energy metabolism in cancer cells (e.g. GAPD, SLC16A3, SLC2A1, and SLC2A8). The gene discussed is GAPDH; the disease is cancer.