Annotation of the majority of these genes (BMPR2, BRD7, ING1, MGA, PRRT2, RASA1, RNF128, SLC16A1, SPRED1, TGIF1, TNRC6B, ZC3H13, ZFP36L2, and ZNF750) has provided convincing evidence for their role in carcinogenesis as tumor suppressors. The gene discussed is BMPR2; the disease is neoplasm.