Annotation of the majority of these genes (BMPR2, BRD7, ING1, MGA, PRRT2, RASA1, RNF128, SLC16A1, SPRED1, TGIF1, TNRC6B, ZC3H13, ZFP36L2, and ZNF750) has provided convincing evidence for their role in carcinogenesis as tumor suppressors. This evidence concerns the gene ZC3H13 and neoplasm.