KRAS and cancer: It is intriguing how reovirus induces the expression of mutated KRAS. It is apparent that whether reoviral machinery induced the expression of KRAS or the cancer cell’s response to virus invasion is manifested by boosting up KRAS expression, it had overall favorable consequences involving cancer cell lysis and release of infective virions which are now capable of infecting neighboring cancer cells, thus generating a self-renewable therapeutic source.