MAPT and early-onset autosomal dominant Alzheimer disease: In contrast, neurofibrillary tanglesin chronic traumatic encephalopathy neuropathologic change showed a more uniformdistribution across the cortex in sections stained for either hyperphosphorylated (sulcaldepth to gyral crest ratio of neurofibrillary tangles 1.40 ± 0.74) or Alzheimer’s diseaseconformation tau (sulcal depth to gyral crest ratio 1.64 ± 1.05), which was comparable tothat seen in material from patients with known Alzheimer’s disease neuropathologic changes(P = 0.82 and P = 0.91, respectively).