Compared to minor allele noncarriers, individuals with either the PPP2R2B rs76752255-C or IGF2BP3 rs117402302-A alleles displayed higher tau on a voxel level in an Alzheimer’s disease-pattern distribution, with predominant clusters in the medial, lateral and inferior temporal and posterior cingulate regions (Fig. 4 and Supplementary Table 5). Here, PPP2R2B is linked to early-onset autosomal dominant Alzheimer disease.