Of interest, all of the genes listed earlier (with the exception for ERCC5) were also mutated in the publicly available dataset of metastatic BC (n = 216 (Lefebvre et al., 2016)), with a total frequency of 3.7% (Cbioportal for cancer genomics; https://www.cbioportal.org) (Figure S11C), thus indicating a potential role in metastatic processes in BC. Here, ERCC5 is linked to cancer.