IL1R1 and breast cancer: Of interest, among these protein interaction networks derived from the “core genes” identified here, the expression levels of COL4A1, IL-10, IL1R1, and PDGFB were positively correlated with poor prognosis in BC patients in terms of 5-year survival data analyzed from the publicity available dataset of Breast Invasive Carcinoma (n = 1,075) from The Cancer Genome Atlas (TCGA) (Figure S10).