PIK3CA and breast cancer: This is also of importance due to the role of PI3K/AKT activation and PTEN loss in TNBC, as previously reported (Bianchini et al., 2016) and as observed here using gene-expression data from different public BC datasets, which showed that PTEN expression levels were lower in the TNBC dataset (i.e., Brown (Burstein et al., 2015)) than in other BC datasets (n = 1779, p = 7.3 × 10−116; data not shown).