Lastly, the expression of syntenin-1 was shown to promote lung metastasis by influencing the inflammatory network, with the induction of inflammatory cytokines (i.e., IL-17A, IL-6) and both inflammatory and immunosuppressive cells (i.e., Th17 cells and MDSCs, respectively) in the TME of metastatic melanoma (Das et al., 2016). The gene discussed is IL6; the disease is metastatic melanoma.