miR-320 overexpression in PCa cells plays a tumor-suppressive role by decreasing PCa tumorigenesis in vitro and in vivo through targeting of lymphoid enhancer-binding factor 1 (LEF1), CD44, SOX9, Oct-4 and CCND1, all associated with the Wnt/β-catenin signaling pathway[95]. Here, LEF1 is linked to posterior cortical atrophy.