MT-TL1 and MELAS: The first report of a mt-tRNA mutation causing human disease was published in 1990 when Kobayashi et al.[11] revealed that a mutation in the mitochondrial tRNALeu gene (MTTL1) was causative of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)[11,12].