OTOF and auditory neuropathy: For example, in Spanish population, the prevalence of nonsyndromic ANSD caused by mutations in the OTOF gene was estimated to be 87%, and the hotspot mutation is c.2485C>T (p.Gln829Ter) [27, 28], while the prevalence is 57% in the Japanese population, and the hotspot mutation is c.5816G>A (p.Arg1939Gln) [29, 30].