EGFR and lung adenocarcinoma: Herein, we analyze B7-H3-induced signaling and its potential correlation with EGFR signaling in lung adenocarcinoma H3255 (L858R) and HCC827 (Del E746-A750) cells and explore the promising combination of B7-H3-targeted immunotherapy and EGFR-targeted therapy in lung adenocarcinoma.