SNHG12 and non-small cell lung carcinoma: In addition, the flow cytometry results showed that knockdown of SNHG12 expression significantly promoted early apoptosis in DU145 cells and upregulated the caspase-3, suggesting that knockdown of SNHG12 induced cell early apoptosis through the caspase signaling pathway, which is consistent with the functions of SNHG12 in NSCLC cells [28].