In addition, the flow cytometry results showed that knockdown of SNHG12 expression significantly promoted early apoptosis in DU145 cells and upregulated the caspase-3, suggesting that knockdown of SNHG12 induced cell early apoptosis through the caspase signaling pathway, which is consistent with the functions of SNHG12 in NSCLC cells [28]. Here, CASP3 is linked to non-small cell lung carcinoma.