CCN2 and neoplasm: The pooled results demonstrate that elevated levels of CTGF were significantly associated with multiple tumors (OR = 2.19, 95% CI: 1.23-3.90), larger tumor size (OR = 1.40, 95% CI: 1.01-1.93), advanced age (OR = 1.38, 95% CI: 1.06-1.79), and vascular invasion (OR = 1.46, 95% CI: 1.03-2.08; Table 2, Figure 2).