Activation of TLR4 can induce the production and secretion of proinflammatory cytokine, while AAD is frequently accompanied by a systemic inflammatory response and severe coagulopathies, which may be provoked by acute aortic injury and reflected in an increment in serum levels of WBC count, CRP, and D-dimer [8, 40, 41]. The gene discussed is TLR4; the disease is blood coagulation disease.