Cell lines in conventional two-dimensional (2D) monolayer culture can be easily used for high throughput drug screens, and this has revealed several compounds and combinations that might be beneficial for chondrosarcoma patients, including ABT-737 (Bcl-2 inhibitor) in combination with doxorubicin (van Oosterwijk et al., 2012b), YM-155 (Survivin inhibitor) (de Jong et al., 2016b), sapanisertib (mTOR inhibitor) (Addie et al., 2019), as well as radiotherapy (de Jong et al., 2019; Venneker et al., 2019). Here, MTOR is linked to chondrosarcoma.