For examples, protein FBXO11 has both the E3 ubiquitin ligase and methyltrasferase activity, which could facilitate epithelial-mesenchymal transition (EMT), promote PI3K/AKT pathway activation, and regulate metastasis and apoptosis in human cancer (Kim et al., 2018, 2020; Sun et al., 2018). The gene discussed is AKT1; the disease is cancer.