The univariate analyses indicated that these factors significantly associated with refractory AOSD: fever, skin rash, arthritis, splenomegaly, hepatomegaly, pleuritis, pneumonia, ferritin ≥ 3,427 ng/ml, ESR ≥ 69 mm/h, CRP ≥ 127.5 mg/L, N% ≥ 86.3%, Hb ≤ 109.5 g/L, LDH ≥ 450 IU/L, ALT ≥ 87 IU/L, AST ≥ 111 IU/L, ALP ≥ 141 IU/L, GGT ≥ 132 IU/L, preAlb ≤ 163 mg/L, Alb ≤ 31.5 g/L or PT ≥ 13.55s. The gene discussed is GSTM1; the disease is Splenomegaly.