CTSL and cancer: However, cancer-related mutations affected expression of SARS-CoV-2 entry genes in adenocarcinoma patients from a previous study (55), where the Kirsten Rat Sarcoma virus (KRAS) mutation was associated with slight but significant decrease in expression of ACE2 and TMPRSS2, and the epidermal growth factor receptor (EGFR) mutation was associated with increased expression of ACE2 and TMPRSS2 and decreased expression of cathepsin L (Supplementary Figure 9).