It was previously reported that p53 is involved in the pathogenesis of HD (Steffan et al., 2000; Trettel et al., 2000) and ployQ-expanded HTT results in transcription dysregulation by interacting with transcription factors such as p53 (Yu et al., 2002; Schaffar et al., 2004; Bae et al., 2005; Cong et al., 2005). Here, TP53 is linked to Huntington disease.