AST significantly upregulates the expression of Bcl-2, particularly in the mitochondria of cardiomyocytes, and inhibits mitochondrial ROS generation, maintains MMP, regulates mPTPs opening, inhibits H9c2 cardiomyocyte apoptosis, promotes the recovery of rat myocardial function, and reduces the area of myocardial infarction. The gene discussed is BCL2; the disease is myocardial infarction.