Recently, novel reports identify a role for MAML1 in T-cell acute lymphoblastic leukemia (T-ALL) in the axis MAML1-SP1-TRIM59, and in breast cancer through the miR-133a-3p/MAML1/DNMT3A positive feedback loop, indicating MAML1 as a potential therapeutic target for these pathological contexts (Cheng et al., 2019; Shi et al., 2019). Here, MAML1 is linked to acute lymphoblastic leukemia.