The role of MAML1 and MAML2, as novel regulators of YAP/TAZ, impinges on the oncogenic properties of the Hippo pathway, involved in the onset and progression of different human cancers (Lin et al., 2018), including colon and lung cancer, where the high levels of MAML1 and MAML2 positively correlate with poor prognosis, emphasizing the MAML1 and MAML2 ability to promote YAP-mediated tumorigenesis. The gene discussed is MAML1; the disease is cancer.