Ca2+ influx via STIM2-mediated SOCE regulates CaMKII and stabilizes mushroom spines (Sun et al., 2014), but we cannot exclude the possible effects of other players of SOCE on abnormal AMPAR diffusion in spines in HD that were shown to act through BDNF-TrkB-CaMKII signaling (Zhang et al., 2018). Here, BDNF is linked to Huntington disease.