There are several points of mHTT interference with MSN Ca2+ signaling that are upstream of the SOCE pathway (Figure 2), and their dysregulation may cause elevations of SOCE in HD models, such as IP3R1 (Wu et al., 2016; Czeredys et al., 2018) and S1R (Ryskamp et al., 2017) signaling. The gene discussed is ITPR1; the disease is Huntington disease.