Or, given the non-apoptotic roles of caspase-2, we could possibly paraphrase this to “life by 20 cuts.” While catalytic independent functions of caspase-2 have been described, such as in the regulation of p21 expression (Sohn et al., 2011), tumor suppression associated with caspase-2 can be blocked by mutation of its catalytic cysteine (Ren et al., 2012). Here, CASP2 is linked to neoplasm.