Our results demonstrated that EGCG was effective in suppressing the phosphorylation of NF-κB, inhibiting the expression of MDM2, and activating the downstream proteins of Bcl-2 and PARP, and then promoted the apoptosis induction, which might contribute to the synergistic effect of combination with DOX against bladder cancer proliferation and migration. This evidence concerns the gene BCL2 and urinary bladder carcinoma.