Further, inhibitor of DNA binding 1 (Id1) mediates the stemness of colorectal cancer cells through the Id1-c-Myc-PLAC8 axis via the Wnt/β-catenin and Shh signaling pathways (Sun et al., 2019) and upregulation of PAG1/CBP contributes to adipose-derived mesenchymal stem cell-promoted tumor progression and chemoresistance in BC (Lu et al., 2017). The gene discussed is SHH; the disease is colorectal cancer.