Interestingly, using bioinformatics-based algorithms for functional characterization, we also showed that HHEX is a targetable gene that has a high degree of gene neighborhood, and it is a probable modulator of survival genes, including BLNK, PAG1, and LPXN as well as known markers of cancer stemness, namely CXCL12, in patients with BC. This evidence concerns the gene CXCL12 and breast cancer.