Sesn2 also prevents age-related intolerance to myocardial infarction via AMPK/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway (Quan et al., 2018), ischemia and reperfusion injury (Quan et al., 2017), atrial fibrillation (Dong Z. et al., 2017), radiation-induced myocardium damage (Zeng et al., 2016) in human and rodent models. The gene discussed is PPARGC1A; the disease is myocardial infarction.