SESN2 and Hypertension: Sesn2 is induced in patients with hypertension (Fang et al., 2020) and overexpressed Sesn2 was protective against cardiomyopathy (Li et al., 2019; Wang P. et al., 2019) and cardiac dysfunction via extracellular signal-regulated protein kinases (ERK)1/2 inhibition (Dong B. et al., 2017) and liver kinase B (LKB)1-mediated AMPK activation (Morrison et al., 2015).