The role of NaCT (SLC13A5) in supplying extracellular citrate has been documented at least in hepatocellular carcinoma and liver cancer cells (Inoue et al., 2003; Li et al., 2017; Kopel et al., 2020); this process is essential for the growth and proliferation of liver cancer cells in vitro and in vivo. This evidence concerns the gene SLC13A5 and liver cancer.