CIBERSORT analysis further indicated that HCC patients with high CIFI values had a significantly higher fraction of Tregs, which have been shown to be enriched in HCC and to inhibit IFN-gamma secretion and the cytotoxicity of CD8 + T cells (Yang et al., 2012; Langhans et al., 2019). The gene discussed is IFNG; the disease is hepatocellular carcinoma.