Interestingly, mutations in C19orf12 cause other neurodegenerative disorders such as hereditary spastic paraplegia phenotype 43 (SPG43) (Landouré et al., 2013), pallido-pyramidal syndrome (Kruer et al., 2014), and juvenile Amyotrofic Lateral Syndrome (Deschauer et al., 2012). The gene discussed is C19orf12; the disease is parkinsonian-pyramidal syndrome.