Interestingly, in the context of CLD, MSC-EVs have been proven to regulate different molecular pathways in liver cells, such as the TGF-β/SMAD, the LPS/TLR4, the STAT3/Bcl-2/Beclin, and the Wnt signaling pathway. This evidence concerns the gene BCL2 and congenital secretory chloride diarrhea 1.