What's more, E-cadherin expression level was decreased and expression levels of N-cadherin, Vimentin, Snail, Slug, and Twist1 were increased in GPER1 overexpressed AGS and MGC-803 cell line (Figure 6E), which trends are also opposite to those observed in GPER1 knockdown GC cell lines. The gene discussed is SNAI1; the disease is gastric cancer.