For example, estradiol (E2) induces proliferation of BPH-10-3 thyroid cancer cells in a concentration and time-dependent manner, resulting in overexpression of phosphorylation AKT/mTOR; these effects were reversed by G15, a GPER1-specific inhibitor (Manfroi et al., 2020). The gene discussed is GPER1; the disease is thyroid gland carcinoma.