On the contrary, G1, a GPER1 agonist, inhibited the proliferation and apoptosis of A549 lung cancer cells mediated by oxidant and antioxidant molecules (Kurt et al., 2015), and suppressed the migration and angiogenesis of triple negative breast cancer cells through suppressing the NF-κB/IL-6 pathway (Liang et al., 2017). This evidence concerns the gene GPER1 and lung carcinoma.