Consistently, positive regulators of Akt signaling, such as Akt (Z-score = 1.626, p = 1.18E–06), IGF2 (Z-score = 2.025, p = 4.70E–10), TGFA (Z-score = 2.251, p = 1.96E–04), and MAPK8 (Z-score = 2.231, p = 4.01E–05), were activated in recurrent colorectal cancers (Figure 4D). Here, MAPK8 is linked to colorectal cancer.