Previous studies reported that miR-224-3p promotes breast cancer development by targeting FUT4 (Feng et al., 2016), promotes cervical cancer by repressing FIP200-mediated autophagy (Fang et al., 2016), and participates in the recurrence of human osteosarcoma (Xu et al., 2018). Here, RB1CC1 is linked to osteosarcoma.