Targeted ablation of these circadian proteins BMAL1 and CLOCK results in infertility in mice with significant characteristic morphological alterations of CBs (Peruquetti et al., 2012) which are clearly different from those observed in mice lacking pGRTH (KI) (Kavarthapu et al., 2019) and GRTH null mice (Tsai-Morris et al., 2004). The gene discussed is BMAL1; the disease is Infertility.